Cardiac Proteomics and Signalling Laboratory


171. Chung NC, Mirza B, Choi H, Wang J, Wang D, Ping P, Wang W. Unsupervised classification of multi-omics data during cardiac remodeling using deep learning. Methods. 2019 Aug 15;166:66-73. doi: 10.1016/j.ymeth.2019.03.004. Epub 2019 Mar 7. PubMed PMID: 30853547; PubMed Central PMCID: PMC6708480.

170. Mirza B, Wang W, Wang J, Choi H, Chung NC, Ping PMachine Learning and Integrative Analysis of Biomedical Big Data. Genes (Basel). 2019 Jan 28;10(2). doi: 10.3390/genes10020087. Review. PubMed PMID: 30696086; PubMed Central PMCID: PMC6410075.

169. Wang J, Choi H, Chung NC, Cao Q, Ng DCM, Mirza B, Scruggs SB, Wang D, Garlid AO, Ping PIntegrated Dissection of Cysteine Oxidative Post-translational Modification Proteome During Cardiac Hypertrophy. J Proteome Res. 2018 Dec 7;17(12):4243-4257. doi: 10.1021/acs.jproteome.8b00372. Epub 2018 Aug 31. PubMed PMID: 30141336; PubMed Central PMCID: PMC6650147.

168. Caufield, J. H., Zhou, Y., Garlid, A. O., Liem, D. A., Cao, Q., Lee, J. M., Murali, S., Spendlove, S., Wang, W., Zhang, L., Sun, Y., Han, J., Watson, K. A., & Ping, P. A reference set of curated biomedical data in clinical case reports. Sci. Data 2018 Nov 20. doi: 10.1038/sdata.2018.258. PubMed PMID: 30457569.

167. Caufield, J. H., Liem, D. A., Garlid, A. O., Watson, K., Bui, A. T., Wang, W., & Ping, P. A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts. JoVE 2018 Sep 20. doi: 10.3791/58392. PubMed PMID: 30295669.

166. Liem, D., Murali, S., Sigdel, D., Shi, Y., Wang, X., Shen, J., Choi, H., Caufield, J. H., Wang, W., Ping, P., & Han, J. Phrase Mining of Textual Data to Analyze Extracellular Matrix Protein Patterns Across Cardiovascular Disease. Am J Physiol Heart Circ Physiol. 2018 May 18. doi: 10.1152/ajpheart.00175.2018. PubMed PMID: 29775406.

165. Flow-Responsive Vascular Endothelial Growth Factor Receptor-Protein Kinase C Isoform Epsilon Signaling Mediates Glycolytic Metabolites for Vascular Repair. Baek KI, Li R, Jen N, Choi H, Kaboodrangi A, Ping P, Liem D, Beebe T, Hsiai TK. Antioxid Redox Signal. 2018 Jan 1;28(1):31-43. doi:10.1089/ars.2017.7044. PubMed PMID: 28762754; PubMed Central PMCID: PMC5695747.

164. Lau E, Cao Q, Lam MPY, Wang J, Ng DCM, Bleakley BJ, Lee JM, Liem DA, Wang D, Hermjakob H, Ping P. Integrated omics dissection of proteome dynamics during cardiac remodeling. Nat Commun. 2018 Jan 9;9(1):120 doi:10.1038/s41467-017-02467-3. PubMed PMID: 29317621

163. Jagodnik KM, Koplev S, Jenkins SL, Ohno-Machado L, Paten B, Schurer SC, Dumontier M, Verborgh R, Bui A, Ping P, McKenna NJ, Madduri R, Pillai A, Ma'ayan A. Developing a framework for digital objects in the Big Data to Knowledge (BD2K) commons: Report from the Commons Framework Pilots workshop. J Biomed Inform. 2017 Jul;71:49-57. doi: 10.1016/j.jbi.2017.05.006. Epub 2017 May 10. PMID: 28501646

162. Perez-Riverol Y, Bai M, da Veiga Leprevost F, Squizzato S, Park YM, Haug K, Carroll AJ, Spalding D, Paschall J, Wang M, Del-Toro N, Ternent T, Zhang P, Buso N, Bandeira N, Deutsch EW, Campbell DS, Beavis RC, Salek RM, Sarkans U, Petryszak R, Keays M, Fahy E, Sud M, Subramaniam S, Barbera A, Jiménez RC, Nesvizhskii AI, Sansone SA, Steinbeck C, Lopez R, Vizcaíno JA, Ping P, Hermjakob H. Discovering and linking public omics data sets using the Omics Discovery Index. Nat Biotechnol. 2017 May 9;35(5):406-409. doi: 10.1038/nbt.3790. No abstract available. PMID: 28486464

161. Ping P, Watson K, Han J, Bui A. Individualized Knowledge Graph: A Viable Informatics Path to Precision Medicine. Circ Res. 2017 Mar 31;120(7):1078-1080. doi: 10.1161/CIRCRESAHA.116.310024. No abstract available. PMID: 28360346

160. Wang J, Lee J, Liem D, Ping P. HSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum. Gene. 2017 Jun 30;618:14-23. doi: 10.1016/j.gene.2017.03.005. Epub 2017 Mar 7. Review. PMID: 28286085

159. Lam MP, Ping P, Murphy E. Proteomics Research in Cardiovascular Medicine and Biomarker Discovery. J Am Coll Cardiol. 2016 Dec 27;68(25):2819-2830. doi: 10.1016/j.jacc.2016.10.031. Review. PMID: 28007144

158. Garlid AO, Polson JS, Garlid KD, Hermjakob H, Ping P. Equipping Physiologists with an Informatics Tool Chest: Toward an Integrated Mitochondrial Phenome. Handb Exp Pharmacol. 2016 Dec 20. [Epub ahead of print] PMID: 27995389

157. Lam MP, Lau E, Ng DC, Wang D, Ping P. Cardiovascular proteomics in the era of big data: experimental and computational advances. Clin Proteomics. 2016 Dec 5;13:23. eCollection 2016. Review. PMID: 27980500

156. Fu S, Ping P, Luo L, Ye P. Deep analyses of the associations of a series of biomarkers with insulin resistance, metabolic syndrome, and diabetes risk in nondiabetic middle-aged and elderly individuals: results from a Chinese community-based study. Clin Interv Aging. 2016 Oct 27;11:1531-1538. eCollection 2016. PMID: 27822025

155. Lam MP, Venkatraman V, Xing Y, Lau E, Cao Q, Ng DC, Su AI, Ge J, Van Eyk JE, Ping P. Data-Driven Approach To Determine Popular Proteins for Targeted Proteomics Translation of Six Organ Systems. J Proteome Res. 2016 Nov 4;15(11):4126-4134. Epub 2016 Jul 19. PMID: 27356587

154. Lau E, Watson KE, Ping P. Connecting the Dots: From Big Data to Healthy Heart. Circulation. 2016 Aug 2;134(5):362-4. doi: 10.1161/CIRCULATIONAHA.116.021892. No abstract available. PMID: 27481999

153. Scruggs SB, Wang D, Ping P. PRKCE gene encoding protein kinase C-epsilon-Dual roles at sarcomeres and mitochondria in cardiomyocytes. Gene. 2016 Sep 15;590(1):90-6. doi: 10.1016/j.gene.2016.06.016. Epub 2016 Jun 13. Review. PMID: 27312950

152. Tsueng G, Good BM, Ping P, Golemis E, Hanukoglu I, van Wijnen AJ, Su AI. Gene Wiki Reviews-Raising the quality and accessibility of information about the human genome. Gene. 2016 Nov 5;592(2):235-8. doi: 10.1016/j.gene.2016.04.053. Epub 2016 May 2. PMID: 27150585

151. Murphy E, Ardehali H, Balaban RS, DiLisa F, Dorn GW 2nd, Kitsis RN, Otsu K, Ping P, Rizzuto R, Sack MN, Wallace D, Youle RJ; American Heart Association Council on Basic Cardiovascular Sciences, Council on Clinical Cardiology, and Council on Functional Genomics and Translational Biology. Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement From the American Heart Association. Circ Res. 2016 Jun 10;118(12):1960-91. doi: 10.1161/RES.0000000000000104. Epub 2016 Apr 28. Review. PMID: 27126807

150. Lau E, Cao Q, Ng DC, Bleakley BJ, Dincer TU, Bot BM, Wang D, Liem DA, Lam MP, Ge J, Ping P. A large dataset of protein dynamics in the mammalian heart proteome. Sci Data. 2016 Mar 15;3:160015. doi: 10.1038/sdata.2016.15. PMID: 26977904

149. Woo JS, Srikanth S, Nishi M, Ping P, Takeshima H, Gwack Y. Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells. Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2762-7. doi: 10.1073/pnas.1524229113. Epub 2016 Feb 29. PMID: 26929330

148. Lin L, Jiang P, Park JW, Wang J, Lu ZX, Lam MP, Ping P, Xing Y. The contribution of Alu exons to the human proteome. Genome Biol. 2016 Jan 28;17:15. doi: 10.1186/s13059-016-0876-5. PMID: 26821878

147. Antman EM, Benjamin EJ, Harrington RA, Houser SR, Peterson ED, Bauman MA, Brown N, Bufalino V, Califf RM, Creager MA, Daugherty A, Demets DL, Dennis BP, Ebadollahi S, Jessup M, Lauer MS, Lo B, MacRae CA, McConnell MV, McCray AT, Mello MM, Mueller E, Newburger JW, Okun S, Packer M, Philippakis A, Ping P, Prasoon P, Roger VL, Singer S, Temple R, Turner MB, Vigilante K, Warner J, Wayte P; American Heart Association Data Sharing Summit Attendees. Acquisition, Analysis, and Sharing of Data in 2015 and Beyond: A Survey of the Landscape: A Conference Report From the American Heart Association Data Summit 2015. J Am Heart Assoc. 2015 Nov 5;4(11). pii: e002810. doi: 10.1161/JAHA.115.002810. PMID: 26541391

146. Grose JH, Langston K, Wang X, Squires S, Mustafi SB, Hayes W, Neubert J, Fischer SK, Fasano M, Saunders GM, Dai Q, Christians E, Lewandowski ED, Ping P, Benjamin IJ. Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. PLoS One. 2015 Oct 14;10(10):e0133994. doi: 10.1371/journal.pone.0133994. eCollection 2015. PMID: 26465331

145. Zhang Y, Xu T, Shan B, Hart J, Aslanian A, Han X, Zong N, Li H, Choi H, Wang D, Acharya L, Du L, Vogt PK, Ping P, Yates JR 3rd. ProteinInferencer: Confident protein identification and multiple experiment comparison for large scale proteomics projects. J Proteomics. 2015 Nov 3;129:25-32. doi: 10.1016/j.jprot.2015.07.006. Epub 2015 Jul 18. PMID: 26196237

144. Ping P, Gustafsson ÅB, Bers DM, Blatter LA, Cai H, Jahangir A, Kelly D, Muoio D, O'Rourke B, Rabinovitch P, Trayanova N, Van Eyk J, Weiss JN, Wong R, Schwartz Longacre L. Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative. Circ Res. 2015 Jul 17;117(3):234-8. doi: 10.1161/CIRCRESAHA.117.306693. PMID: 26185209

143. Lam MP, Venkatraman V, Cao Q, Wang D, Dincer TU, Lau E, Su AI, Xing Y, Ge J, Ping P, Van Eyk JE. Prioritizing Proteomics Assay Development for Clinical Translation. J Am Coll Cardiol. 2015 Jul 14;66(2):202-4. doi: 10.1016/j.jacc.2015.04.072. No abstract available. PMID: 26160638

142.  Semba RD, Lam M, Sun K, Zhang P, Schaumberg DA, Ferrucci L, Ping P, Van Eyk JE. Priorities and trends in the study of proteins in eye research, 1924-2014. Proteomics Clin Appl. 2015 Jun 29. doi: 10.1002/prca.201500006. PMID:26123431

141. Lindskog C, Linné J, Fagerberg L, Hallström BM, Sundberg CJ, Lindholm M, Huss M, Kampf C, Choi H, Liem DA, Ping P, Väremo L, Mardinoglu A, Nielsen J, Larsson E, Pontén F, Uhlén M. The human cardiac and skeletal muscle proteomes defined by transcriptomics and antibody-based profiling. BMC Genomics. 2015 Jun 25;16(1):475. doi: 10.1186/s12864-015-1686-y. PMID: 26109061

140. Lau E, Huang D, Cao Q, Dincer TU, Black CM, Lin AJ, Lee JM, Wang D, Liem DA, Lam MP, Ping P. Spatial and temporal dynamics of the cardiac mitochondrial proteome. Expert Rev Proteomics. 2015 Apr;12(2):133-46. doi: 10.1586/14789450.2015.1024227. Epub 2015 Mar 9. PMID: 25752359 

139. Scruggs SB, Watson K, Su AI, Hermjakob H, Yates JR 3rd, Lindsey ML, Ping P. Harnessing the heart of big data. Circ Res. 2015 Mar 27;116(7):1115-9. doi: 10.1161/CIRCRESAHA.115.306013. No abstract available. PMID: 25814682

138. Lotz C, Zhang J, Fang C, Liem D, Ping P. Isoflurane protects the myocardium against ischemic injury via the preservation of mitochondrial respiration and its supramolecular organization. Anesth Analg. 2015 Feb;120(2):265-74. doi: 10.1213/ANE.0000000000000494. PMID: 25383718

137.  Chan XC, Black CM, Lin AJ, Ping P, Lau E. Mitochondrial protein turnover: methods to measure turnover rates on a large scale. J Mol Cell Cardiol. 2015 Jan;78:54-61. doi: 10.1016/j.yjmcc.2014.10.012. Epub 2014 Nov 11. Review. PMID:25451168

136.  Calmettes G, Ribalet B, John S, Korge P, Ping P, Weiss JN. Hexokinases and cardioprotection. J Mol Cell Cardiol. 2015 Jan;78:107-15. doi: 10.1016/j.yjmcc.2014.09.020. Epub 2014 Sep 26. Review. PMID: 25264175 

135. Siu KL, Lotz C, Ping P, Cai H. Netrin-1 abrogates ischemia/reperfusion-induced cardiac mitochondrial dysfunction via nitric oxide-dependent attenuation of NOX4 activation and recoupling of NOS. J Mol Cell Cardiol. 2014 Jul 24. doi: 10.1016/j.yjmcc.2014.07.005. PMID: 25066694

134. Zong N, Ping P, Lau E, Choi HJ, Ng DC, Meyer D, Fang C, Li H, Wang D, Zelaya IM, Yates JR 3rd, Lam MP. Lysine Ubiquitination and Acetylation of Human Cardiac 20S Proteasomes. Proteomics Clin Appl. 2014 Aug;8(7-8):590-4. doi: 10.1002/prca.201400029. PMID: 24957502

133. Wang D, Liem DA, Lau E, Ng DC, Bleakley BJ, Cadeiras M, Deng MC, Lam MP, Ping P. Characterization of human plasma proteome dynamics using deuterium oxide. Proteomics Clin Appl. 2014 Aug;8(7-8):610-9. doi: 10.1002/prca.201400038. PMID: 24946186

132. Chan X, Wang D, Madeiras M, Deng MC, Ping P. S-nitrosylation of TRIM72 mends the broken heart: A molecular modifier-mediated cardioprotection. J Mol Cell Cardiol. 2014 Jul;72C:292-295. doi: 10.1016/j.yjmcc.2014.04.004. PMID: 24735828

131. Lam MP, Wang D, Lau E, Liem DA, Kim AK, Ng DCM, Liang X, Bleakley BJ, Liu C, Tabaraki JD, Cadieras M, Wang Y, Deng MC, Ping P. Protein kinetic signatures of the remodeling heart following isoproternol stimulation. J Clin Invest. 2014; 124(4):1734-44. PMCID: PMC3973111. PMID: 24614109

130. Liem DA, Nsair A, Setty SP, Cadieras M, Wang D, Maclellan R, Lotz C, Lin AJ, Tabaraki J, Larson E, Mulder J, Lundberg E, Weiss JN, Uhlen M, Ping P, Deng MC. Molecular- and organelle-based predictive paradigm underlying recovery by left ventricular assist device support. Circ Heart Fail. 2014 Mar;7(2):359-66. doi: 10.1161/CIRCHEARTFAILURE.113.000250. PMID: 24643888

129. Lu G, Ota A, Ren S, Franklin S, Rau CD, Ping P, Lane TF, Zhou ZH, Reue K, Lusis AJ, Vondriska T, Wang Y. PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response. Mol Metab. 2013 Aug 3;2(4):405-16.  PMCID: PMC3854994. PMID: 24327956 

128. Lam MP, Lau E, Liem DA, Ping P. Cyclophilin D and acetylation: a new link in cardiac signaling. Circ Res. 2013 Dec 6;113(12):1268-9. doi: 10.1161/CIRCRESAHA.113.302687. PMID: 24311610

127. Cui Z, Scruggs SB, Gilda JE, Ping P, Gomes AV. Regulation of cardiac proteasomes by ubiquitination, SUMOylation, and beyond. J Mol Cell Cardiol. 2014;71:32-42.  PMCID:PMC3990655. PMID: 24327956

126. Lotz C, Lin AJ, Black CM, Zhang J, Lau E, Deng N, Wang Y, Zong NC, Choi JH, Xu T, Liem DA, Korge P, Weiss JN, Hermjakob H, Yates JR, Apweiler R, Ping P. The Characterization, Design, and Function of the Mitochondrial Proteome: From Organs to Organisms. J Proteome Res. 2014 Feb 7;13(2):433-46. PMCID: PMC4076470. PMID: 24070373 

125. Wang D, Fang C, Zong NC, Liem DA, Cadeiras M, Scruggs SB, Yu H, Kim AK, Yang P, Deng M, Lu H, Ping P. Regulation of acetylation restores proteolytic function of diseased myocardium in mouse and human. Mol Cell Proteomics. 2013 Dec;12(12):3793-802.  PMCID: PMC3861724. PMID: 24037710

124. Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR 3rd, Apweiler R, Ge J, Hermjakob H, Ping P. Integration of cardiac proteome biology and medicine by a specialized knowledgebase. Circ Res. 2013 Oct 12;113(9):1043-53.  PMCID: PMC4076475. PMID: 23965338

123. Chan CX, Khan AA, Choi JH, Ng CD, Cadeiras M, Deng M, Ping P. Technology platform development for targeted plasma metabolites in human heart failure. Clin Proteomics. 2013 Jul 4;10(1):7. PMCID: PMC3708771. PMID: 23826926

122. Youn JY, Zhang J, Zhang Y, Chen H, Liu D, Ping P, Weiss JN, Cai H. Oxidative stress in atrial fibrillation: an emerging role of NADPH oxidase. J Mol Cell Cardiol. 2013 Sep;62:72-9. PMCID: PMC3735724. PMID: 23643589

121. Martin LJ, Lau E, Singh H, Vergnes L, Tarling EJ, Mehrabian M, Mungrue I, Xiao S, Shih D, Castellani L, Ping P, Reue K, Stefani E, Drake TA, Bostrom K, Lusis AJ. Response to Pomozi et al's research commentary. Circ Res. 2013 May 24;112(11):e152-3.  PMCID: PMC3999040. PMID: 23625949

120. Ahuja P, Wanagat J, Wang Z, Wang Y, Liem DA, Ping P, Antoshechkin IA, Margulies KB, Maclellan WR. Divergent mitochondrial biogenesis responses in human cardiomyopathy. Circulation. 2013 May 14;127(19):1957-67. doi: 10.1161/CIRCULATIONAHA.112.001219. PMID: 23589024

119. Gómez J, García LJ, Salazar GA, Villaveces J, Gore S, García A, Martín MJ, Launay G, Alcántara R, Del-Toro N, Dumousseau M, Orchard S, Velankar S, Hermjakob H, Zong C, Ping P, Corpas M, Jiménez RC. BioJS: an open source JavaScript framework for biological data visualization. Bioinformatics. 2013 Apr 15;29(8):1103-4.  PMCID: PMC3624812. PMID: 23435069

118. Li H, Zong NC, Liang X, Kim AK, Choi JH, Deng N, Zelaya I, Lam M, Duan H, Ping P. A novel spectral library workflow to enhance protein identifications. J Proteomics. 2013 Apr 9;81:173-84.  PMCID: PMC3737079. PMID: 23391412

117. Lam MP, Lau E, Scruggs SB, Wang D, Kim TY, Liem DA, Zhang J, Ryan CM, Faull KF, Ping P. Site-specific quantitative analysis of cardiac mitochondrial protein phosphorylation. J Proteomics. 2013 Apr 9;81:15-23. doi: 10.1016/j.jprot.2012.09.015. PMID: 23022582 

116. Henze M, Patrick SE, Hinken A, Scruggs SB, Goldspink P, de Tombe PP, Kobayashi M, Ping P, Kobayashi T, Solaro RJ. New insights into the functional significance of the acidic region of the unique N-terminal extension of cardiac troponin I. Biochim Biophys Acta. 2013 Apr;1833(4):823-32. PMCID: PMC3593810. PMID: 23022582

115. Kim TY, Wang D, Kim AK, Lau E, Lin AJ, Liem DA, Zhang J, Zong NC, Lam MP, Ping P. Metabolic Labeling Reveals Proteome Dynamics of Mouse Mitochondria. Mol Cell Proteomics. 2012 Dec;11(12):1586-94.  PMCID: PMC3518123. PMID: 22915825

114. Martin LJ, Lau E, Singh H, Vergnes L, Tarling EJ, Mehrabian M, Mungrue I, Xiao S, Shih D, Castellani L, Ping P, Reue K, Stefani E, Drake TA, Bostrom K, Lusis AJ. ABCC6 Localizes to the Mitochondria-Associated Membrane. Circ Res. 2012;111(5):516-20.  PMCID: PMC3540978. PMID: 22811557

113. Scruggs SB, Zong NC, Wang D, Stefani E, Ping P. Post-translational Modification of Cardiac Proteasomes: Functional Delineation Enabled by Proteomics. Am J Physiol Heart Circ Physiol. 2012;303(1):H9-H18.  PMCID: PMC3404648. PMID: 22523251 

112. Lau E, Wang D, Zhang J, Yu H, Lam MP, Liang X, Zong N, Kim TY, Ping P. Substrate- and Isoform-Specific Proteome Stability in Normal and Stressed Cardiac Mitochondria. Circ Res. 2012;110(9):1174-8. PMCID: PMC3359149. PMID: 22456183 

111. Lam MP, Scruggs SB, Kim TY, Zong C, Lau E, Wang D, Ryan CM, Faull KF, Ping P. An MRM-based workflow for quantifying cardiac mitochondrial protein phosphorylation in murine and human tissue. J Proteomics. 2012;75(15):4602-9.  PMCID: PMC3405178. PMID: 22387130

110. Lotz C, Liem D, Ping P. New frontiers in myocardial protection: a systems biology approach. J Cardiovasc Pharmacol Ther. 2011 Sep-Dec;16(3-4):285-9. doi: 10.1177/1074248411415855. PMID: 21821530

109. Scruggs SB, Ping P, Zong C. Heterogeneous cardiac proteasomes: mandated by diverse substrates? Physiology (Bethesda). 2011 Apr;26(2):106-14. doi: 10.1152/physiol.00039.2010. PMID:21487029

108. Ping P, Mayor T, Huang L. Managing the quality of life for proteins: focusing on the exit path. Introduction. Mol Cell Proteomics. 2011 May;10(5):O111.009969.  PMCID: PMC3098600. PMID: 21441579

107. Wang D, Zong C, Koag MC, Wang Y, Drews O, Fang C, Scruggs SB, Ping P. Proteome dynamics and proteome function of cardiac 19S proteasomes. Mol Cell Proteomics. 2011 May;10(5):M110.006122.  doi: 10.1074/mcp.M110.006122. PMID: 21357515 

106. Deng N, Zhang J, Zong C, Wang Y, Lu H, Yang P, Wang W, Young GW, Wang Y, Korge P, Lotz C, Doran P, Liem DA, Apweiler R, Weiss JN, Duan H, Ping P. Phosphoproteome analysis reveals regulatory sites in major pathways of cardiac mitochondria. Mol Cell Proteomics. 2011 Feb; 10(2):M110.000117.  PMCID: PMC3033665. PMID: 20495213

105. Drews O, Tsukamoto O, Liem D, Streicher J, Wang Y, Ping P. Differential Regulation of Proteasome Function in Isoproterenol-Induced Cardiac Hypertrophy. Circ Res. 2010 Oct 29;107(9):1094-101.  PMCID: PMC3360925. PMID: 20814020

104. Franklin S, Zhang MJ, Chen H, Paulsson AK, Mitchell-Jordan SA, Li Y, Ping P, Vondriska TM. Specialized compartments of cardiac nuclei exhibit distinct proteomic anatomy. Mol Cell Proteomics. 2011 Jan;10(1):M110.000703.  PMCID: PMC3013444. PMID: 20807835

103. Zhang MJ, Franklin S, Li Y, Wang S, Ru X, Mitchell-Jordan SA, Mano H, Stefani E, Ping P, Vondriska TM. Stress signaling by Tec tyrosine kinase in the ischemic myocardium. Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H713-22.  PMCID: PMC2944495. PMID: 20543088

102. Ping P, Chan DW, Srinivas P. Advancing cardiovascular biology and medicine via proteomics: Opportunities and present challenges of cardiovascular proteomics. Circulation. 2010 Jun 1;121(21):2326-8.  PMCID: PMC3566868. PMID: 20516387

101. Lotz C, Ping P, Kehl F. Letter by Lotz et al regarding article, "Reactive oxygen species-induced stimulation of 5' AMP-activated protein kinase mediates sevoflurane-induced cardioprotection". Circulation. 2010 May 11;121(18):e399; author reply e400. doi: 10.1161/CIR.0b013e3181df9134. PMID: 20458019

100. Ota A, Zhang J, Ping P, Han J, Wang Y. Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte. Circ Res. 2010 Apr 30;106(8):1404-12.  PMCID: PMC2891038. PMID: 20299663

99. Ryan CM, Souda P, Bassilian S, Ujwal R, Zhang J, Abramson J, Ping P, Durazo A, Bowie JU, Hasan SS, Baniulis D, Cramer WA, Faull KF, Whitelegge JP. Post-translational modifications of integral membrane proteins resolved by top-down Fourier transform mass spectrometry with collisionally activated dissociation. Mol Cell Proteomics. 2010 May;9(5):791-803.  PMCID: PMC2871414. PMID: 20093275

98. Wu HY, Tseng VS, Chen LC, Chang YC, Ping P, Liao CC, Tsay YG, Yu JS, Liao PC. Combining alkaline phosphatase treatment and hybrid linear ion trap/Orbitrap high mass accuracy liquid chromatography-mass spectrometry data for the efficient and confident identification of protein phosphorylation. Anal Chem. 2009 Sep 15;81(18):7778-87. doi: 10.1021/ac9013435. PMID: 19702290

97. Ujwal R, Cascio D, Chaptal V, Ping P, Abramson J. Crystal packing analysis of murine VDAC1 crystals in a lipidic environment reveals novel insights on oligomerization and orientation. Channels (Austin). 2009 May-Jun;3(3):167-70.  PMCID: PMC3719987. PMID: 19574737

96. Lu G, Sun H, She P, Youn JY, Warburton S, Ping P, Vondriska TM, Cai H, Lynch CJ, Wang Y. Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells. J Clin Invest. 2009 Jun;119(6):1678-87.  PMCID: PMC2689111. PMID: 19411760

95. Rodriguez H, Snyder M, Uhlén M, Andrews P, Beavis R, Borchers C, Chalkley RJ, Cho SY, Cottingham K, Dunn M, Dylag T, Edgar R, Hare P, Heck AJ, Hirsch RF, Kennedy K, Kolar P, Kraus HJ, Mallick P, Nesvizhskii A, Ping P, Pontén F, Yang L, Yates JR, Stein SE, Hermjakob H, Kinsinger CR, Apweiler R. Recommendations from the 2008 International Summit on Proteomics Data Release and Sharing Policy: the Amsterdam principles. J Proteome Res. 2009 Jul;8(7):3689-92.  PMCID: PMC2742685. PMID: 19344107

94. Ping P. Getting to the heart of proteomics. N Engl J Med. 2009 Jan 29;360(5):532-4. PMCID: PMC2692588. PMID: 19179323

93. Orchard S, Ping P. HUPO World Congress Publication Committee meeting. August 2008, Amsterdam, The Netherlands. Proteomics. 2009 Feb;9(3):502-3. doi: 10.1002/pmic.200800839. PMID: 19132689

92. Mayr M, Liem D, Zhang J, Li X, Avliyakulov NK, Yang JI, Young G, Vondriska TM, Ladroue C, Madhu B, Griffiths JR, Gomes A, Xu Q, Ping P. Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts. J Mol Cell Cardiol. 2009 Feb;46(2):268-77. PMCID: PMC3661410. PMID: 19027023

91. Zong C, Young GW, Wang Y, Lu H, Deng N, Drews O, Ping P. Two-dimensional electrophoresis-based characterization of post-translational modifications of mammalian 20S proteasome complexes. Proteomics. 2008 Dec;8(23-24):5025-37.  PMCID: PMC2674022. PMID: 19003867

90. Ujwal R, Cascio D, Colletier JP, Faham S, Zhang J, Toro L, Ping P, Abramson J. The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17742-7. PMCID: PMC2584669. PMID: 18988731

89. Gomes AV, Young GW, Wang Y, Zong C, Eghbali M, Drews O, Lu H, Stefani E, Ping P. Contrasting proteome biology and functional heterogeneity of the 20 S proteasome complexes in mammalian tissues. Mol Cell Proteomics. 2009 Feb;8(2):302-15. PMCID: PMC2634581. PMID: 18931337

88. Korge P, Ping P, Weiss JN. Reactive oxygen species production in energized cardiac mitochondria during hypoxia/reoxygenation: modulation by nitric oxide. Circ Res. 2008 Oct 10;103(8):873-80. PMCID: PMC2755534. PMID: 18776040

87. Liem DA, Zhao P, Angelis E, Chan SS, Zhang J, Wang G, Berthet C, Kaldis P, Ping P, MacLellan WR. Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury. J Mol Cell Cardiol. 2008 Nov;45(5):610-6. PMCID: PMC2603425. PMID: 18692063

86. Lu H, Zong C, Wang Y, Young GW, Deng N, Souda P, Li X, Whitelegge J, Drews O, Yang PY, Ping P. Revealing the dynamics of 20S proteasome phosphoproteome: A combined CID and ETD approach. Molecular & cellular proteomics : MCP (Mol Cell Proteomics). 2008 Nov;7(11):2073-89. PMCID: PMC2577207. PMID: 18579562

85. Zhang J, Liem DA, Mueller M, Wang Y, Zong C, Deng N, Vondriska TM, Korge P, Drews O, Maclellan WR, Honda H, Weiss JN, Apweiler R, Ping P. Altered Proteome Biology of Cardiac Mitochondria Under Stress Conditions. Journal of proteome research (J Proteome Res) 2008 Jun;7(6):2204-14. PMCID: PMC3805274. PMID: 18484766

84. Young GW, Wang Y, Ping P. Understanding proteasome assembly and regulation: importance to cardiovascular medicine. Trends Cardiovasc Med. 2008;18:93-8. PMCID: PMC2441911. PMID: 18436147

83. Zhang J, Li X, Mueller M, Wang Y, Zong C, Deng N, Vondriska TM, Liem DA, Yang JI, Korge P, Honda H, Weiss JN, Apweiler R, Ping P. Systematic characterization of the murine mitochondrial proteome using functionally validated cardiac mitochondria. Proteomics. 2008;8:1564-75.  PMCID: PMC2799225. PMID: 18348319 

82. Baldán A, Gomes AV, Ping P, Edwards PA. Loss of ABCG1 Results in Chronic Pulmonary Inflammation. J Immunol. 2008;180:3560-8. PMID: 18292583

81. Warburton S, White MY, Van Eyk JE, Cotter RJ, Ping P, Dunn MJ, Vondriska TM. Cardiovascular Initiative of the Human Proteome Organisation, 5th Workshop October 2007, Seoul, Korea. Proteomics. 2008;8:924-6. doi: 10.1002/pmic.200701083. PMID: 18240139

80. Ping P, Bergeron J, Apweiler R. Wiley-VCH and HUPO: a global effort to advance proteomic science. Proteomics. 2008;8:4-6. doi: 10.1002/pmic.200790108. PMID: 18095363

79. Taylor CF, Paton NW, Lilley KS, Binz PA, Julian RK Jr, Jones AR, Zhu W, Apweiler R, Aebersold R, Deutsch EW, Dunn MJ, Heck AJ, Leitner A, Macht M, Mann M, Martens L, Neubert TA, Patterson SD, Ping P, Seymour SL, Souda P, Tsugita A, Vandekerckhove J, Vondriska TM, Whitelegge JP, Wilkins MR, Xenarios I, Yates JR 3rd, Hermjakob H. The minimum information about a proteomics experiment (MIAPE). Nat Biotechnol. 2007;25:887-93. doi: 10.1038/nbt1329. PMID: 17687369 

78. Liem DA, Honda HM, Zhang J, Woo D, Ping P. Past and present course of cardioprotection against ischemia-reperfusion injury. J Appl Physiol. 2007;103:2129-36. doi: 10.1152/japplphysiol.00383.2007. PMID: 17673563

77. Drews O, Wildgruber R, Zong C, Sukop U, Nissum M, Weber G, Gomes AV, Ping P. Mammalian proteasome subpopulations with distinct molecular compositions and proteolytic activities. Mol Cell Proteomics. 2007;6:2021-31. doi: 10.1074/mcp.M700187-MCP200. PMID: 17660509

76. Drews O, Zong C, Ping P. Exploring proteasome complexes by proteomic approaches. Proteomics. 2007;7:1047-58. doi: 10.1002/pmic.200600574. PMID: 17390294

75. Orchard S, Heck A, Uhlen M, Ping P. Publication Committee meeting. HUPO 5th annual World Congress. Long Beach, CA, USA 30 October 2006. Proteomics. 2007;7:1009-11. doi: 10.1002/pmic.200700015. PMID: 17340644

74. Kawaguchi R, Yu J, Honda J, Hu J, Whitelegge J, Ping P, Wiita P, Bok D, Sun H. A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science. 2007;315:820-5. doi: 10.1126/science.1136244. PMID: 17255476

73. Honda HM, Ping P. Mitochondrial permeability transition in cardiac cell injury and death. Cardiovasc Drugs Ther. 2006;20:425-32. doi: 10.1007/s10557-006-0642-0. PMID: 17171295

72. Arab S, Gramolini AO, Ping P, Kislinger T, Stanley B, van Eyk J, Ouzounian M, MacLennan DH, Emili A, Liu PP. Cardiovascular proteomics: tools to develop novel biomarkers and potential applications. J Am Coll Cardiol. 2006;48:1733-41. doi: 10.1016/j.jacc.2006.06.063. PMID: 17084242

71. Drake TA, Ping P. Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Proteomics approaches to the systems biology of cardiovascular diseases. J Lipid Res. 2007;48:1-8. DOI: 10.1194/jlr.R600027-JLR200. PMID: 17065662

70. Abdellatif AA, Pelt JL, Benton RL, Howard RM, Tsoulfas P, Ping P, Xu XM, Whittemore, SR. Gene delivery to the spinal cord: comparison between lentiviral, adenoviral, and retroviral vector delivery systems." J Neurosci Res. 2006;84:553-67. PMCID: PMC2862356. PMID: 16786574   

69. Gomes AV, Zong C, Edmondson RD, Li X, Stefani E, Zhang J, Jones RC, Thyparambil S, Wang GW, Qiao X, Bardag-Gorce F, Ping P. Mapping the murine cardiac 26S proteasome complexes. Circ Res. 2006;99:362-71. doi: 10.1161/01.RES.0000237386.98506.f7. PMID: 16857966

68. Gomes AV, Zong C, Ping P. Protein Degradation by the 26S Proteasome System in the Normal and Stressed Myocardium. Antioxid Redox Signal. 2006;8:1677-91. doi: 10.1089/ars.2006.8.1677. PMID: 16987021 

67. Mayr M, Zhang J, Greene AS, Gutterman DD, Perloff JK, Ping P. Proteomic based development of biomarkers in cardiovascular disease: Mechanistic, clinical, and therapeutic insights. Mol Cell Proteomics. 2006;5:1853-1864. doi: 10.1074/mcp.R600007-MCP200. PMID: 16733263    

66. Orchard S, Ping P. HUPO Publications Committee Meeting: 21 April 2006, San Francisco, CA, USA. Proteomics. 2006;6:4436-8. doi: 10.1002/pmic.200600453. PMID: 16897682 

65. Zong C, Gomes AV, Drews O, Li X, Young GW, Berhane B, Qiao X, French SW, Bardag-Gorce F, Ping P. Regulation of murine cardiac 20S proteasomes: role of associating partners. Circ Res. 2006;99:372-80. doi: 10.1161/01.RES.0000237389.40000.02. PMID: 16857963 

64. Berhane BT, Zong C, Liem DA, Huang A, Le S, Edmondson RD, Jones RC, Qiao X, Whitelegge JP, Ping P, Vondriska TM. Cardiovascular-related proteins identified in human plasma by the HUPO Plasma Proteome Project pilot phase. Proteomics. 2005;5:3520-30. doi: 10.1002/pmic.200401308. PMID: 16052623 

63. Cao Q, Xu XM, Devries WH, Enzmann GU, Ping P, Tsoulfas P, Wood PM, Bunge MB, Whittemore SR. Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial-restricted precursor cells. J Neurosci. 2005;25:6947-57.  PMCID: PMC2813488. PMID: 16049170  

62. Gomes AV, Zong C, Edmondson RD, Berhane BT, Wang GW, Le S, Young G, Zhang J, Vondriska TM, Whitelegge JP, Jones RC, Joshua IG, Thyparambil S, Pantaleon, D, Qiao J, Loo J, Ping P. The murine cardiac 26S proteasome: an organelle awaiting exploration. Ann N Y Acad Sci. 2005;1047:197-207. doi: 10.1196/annals.1341.018. PMID: 16093497

61. McCarthy J, McLeod CJ, Minners J, Essop MF, Ping P, Sack MN. PKCepsilon activation augments cardiac mitochondrial respiratory post-anoxic reserve--a putative mechanism in PKCepsilon cardioprotection. J Mol Cell Cardiol. 2005;38:697-700. doi: 10.1016/j.yjmcc.2005.02.010. PMID: 15808847 

60. Omenn GS, Ping P. HUPO 3rd annual World Congress on Proteomics. 25-27th October, 2004, Beijing, China. Expert Rev Proteomics. 2005;2:9-12. doi: 10.1586/14789450.2.1.9. PMID: 15966848 

59. Omenn GS, States DJ, Adamski M, Blackwell TW, Menon R, Hermjakob H, Apweiler R, Haab BB, Simpson RJ, Eddes JA, Kapp EA, Moritz RL, Chan DW, Rai AJ, Admon A, Aebersold R, Eng J, Hancock WS, Hefta SA, Meyer H, Paik YK, Yoo JS, Ping P, Pounds J, Adkins J, Qian X, Wang R, Wasinger V, Wu CY, Zhao X, Zeng R, Archakov A, Tsugita A, Beer I, Pandey A, Pisano M, Andrews P, Tammen H, Speicher DW, Hanash SM. Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database. Proteomics. 2005;5:3226-45. DOI: 10.1002/pmic.200500358. PMID: 16104056 

58. Ping P, Vondriska TM, Creighton CJ, Gandhi TK, Yang Z, Menon R, Kwon, MS, Cho SY, Drwal G, Kellmann M, Peri S, Suresh S, Gronborg M, Molina H, Chaerkady R, Rekha B, Shet AS, Gerszten RE, Wu H, Raftery M, Wasinger V, Schulz-Knappe P, Hanash SM, Paik YK, Hancock WS, States DJ, Omenn GS, Pandey A. A functional annotation of subproteomes in human plasma. Proteomics. 2005;5:3506-19. doi: 10.1002/pmic.200500140. PMID: 16104058

57. Wang G, Liem DA, Vondriska TM, Honda HM, Korge P, Pantaleon DM, Qiao X, Wang Y, Weiss JN, Ping P. Nitric oxide donors protect murine myocardium against infarction via modulation of mitochondrial permeability transition. Am J Physiol Heart Circ Physiol. 2005;288:H1290-5. doi: 10.1152/ajpheart.00796.2004. PMID: 15528225

56. Zhang J, Baines CP, Zong C, Cardwell EM, Wang G, Vondriska TM, Ping P. Functional proteomic analysis of a three-tier PKCepsilon-Akt-eNOS signaling module in cardiac protection. Am J Physiol Heart Circ Physiol. 2005;288:H954-61. doi: 10.1152/ajpheart.00756.2004. PMID: 15528226 

55. MacLellan WR, Ping P, Vondriska T. Heart disease leaves its mark: proteomics-based biosignatures in acute coronary syndromes. J Am Coll Cardiol. 2004;44:1584-6. doi: 10.1016/j.jacc.2004.08.001. PMID: 15489089 

54. Vondriska TM, Pass JM, Ping P. Scaffold proteins and assembly of multiprotein signaling complexes. J Mol Cell Cardiol. 2004;37:391-7. doi: 10.1016/j.yjmcc.2004.04.021. PMID: 15276009

53. Zhang J, Ping P, Wang GW, Lu M, Pantaleon D, Tang XL, Bolli R, Vondriska TM. Bmx, a member of the Tec family of nonreceptor tyrosine kinases, is a novel participant in pharmacological cardioprotection. Am J Physiol Heart Circ Physiol. 2004;287:H2364-6. doi: 10.1152/ajpheart.00416.2004. PMID: 15191890

52. Ping P, Baines CP, Gu Y, Prabhu SD, Zhang J, Tsai LL, Cardwell E, Zong NC, Vondriska TM, Korge P, Bhatnagar A, Wang GW. Cardiac toxic effects of trans-2-hexenal are mediated by induction of cardiomyocyte apoptotic pathways. Cardiovascular toxicology (Cardiovasc Toxicol). 2003;3:341-51. PMID: 14734831

51. Doble BW, Dang X, Ping P, Fandrich RR, Nickel BE, Jin Y, Cattini PA, Kardami E. Phosphorylation of serine 262 in the gap junction protein connexin-43 regulates DNA synthesis in cell-cell contact forming cardiomyocytes. Journal of cell science (J Cell Sci). 2004;117:507-14. doi: 10.1242/jcs.00889. PMID: 14702389

50. Ping P. Identification of novel signaling complexes by functional proteomics. Circulation research (Circ Res). 2003 Oct 3;93(7):595-603. doi: 10.1161/01.RES.0000093221.98213.E0. PMID: 14525921

49. Vondriska TM, Ping P. Multiprotein signaling complexes and regulation of cardiac phenotype. Journal of molecular and cellular cardiology (J Mol Cell Cardiol). 2003 Sep;35:1027-33. PMID: 12967625

48. Weiss JN, Korge P, Honda HM, Ping P. Role of the mitochondrial permeability transition in myocardial disease.Circulation research (Circ Res). 2003;93:292-301. doi: 10.1161/01.RES.0000087542.26971.D4. PMID: 12933700

47. Pass JM, Zhang J, Vondriska TM, Ping P. Functional proteomic analysis of the protein kinase C signaling system. Methods in molecular biology (Clifton, N.J.) (Methods Mol Biol). 2003;233:369-85. doi: 10.1385/1-59259-397-6:369. PMID: 12840523

46. Zhang J, Ping P, Vondriska TM, Tang XL, Wang GW, Cardwell EM, Bolli R. Cardioprotection involves activation of NF-kappa B via PKC-dependent tyrosine and serine phosphorylation of I kappa B-alpha.American journal of physiology. Heart and circulatory physiology (Am J Physiol Heart Circ Physiol). 2003;285:H1753-8. DOI: 10.1152/ajpheart.00416.2003. PMID: 12829431

45. Ping P. A new chapter in cardiac PKC signaling studies: searching for isoform-specific molecular targets. Focus on: "isoenzyme-selective regulation of SERCA2 gene expression by protein kinase C in neonatal rat ventricular myocytes". American journal of physiology. Cell physiology(Am J Physiol Cell Physiol). 2003;285:C19-21. doi: 10.1152/ajpcell.00120.2003. PMID: 12777253

44. Prabhu SD, Wang G, Luo J, Gu Y, Ping P, Chandrasekar B. Beta-adrenergic receptor blockade modulates Bcl-X(S) expression and reduces apoptosis in failing myocardium.(Journal of molecular and cellular cardiology (J Mol Cell Cardiol). 2003;35:483-93. PMID: 12738230 

43. Baines CP, Song CX, Zheng YT, Wang GW, Zhang J, Wang OL, Guo Y, Bolli R, Cardwell EM, Ping P. Protein kinase Cepsilon interacts with and inhibits the permeability transition pore in cardiac mitochondria. Circ Res. 2003;92:873-80.  PMCID: PMC3691672. PMID: 12663490
36. Ping P, Song C, Zhang J, Guo Y, Cao X, Li RC, Wu W, Vondriska TM, Pass JM, Tang XL, Pierce WM, Bolli R. Formation of protein kinase Ce-Lck signaling modules confers cardioprotection. J Clin Invest. 2002;109:499-507. PMCID: PMC150872. PMID: 11854322 
1. Ping P, Johnson PC. Mechanism of enhanced myogenic response in arterioles during sympathetic nerve stimulation. Am J Physiol. 1992;263:H1185-9. PMID: 1384361

42. Tang XL, Kodani E, Takano H, Hill M, Shinmura K, Vondriska TM, Ping P, Bolli R. Protein tyrosine kinase signaling is necessary for NO donor-induced late preconditioning against myocardial stunning.American journal of physiology. Heart and circulatory physiology (Am J Physiol Heart Circ Physiol). 2003;284:H1441-8. DOI: 10.1152/ajpheart.00789.2002. PMID: 12531734

41. Vondriska TM, Ping P. Functional proteomics to study protection of the ischaemic myocardium. Expert opinion on therapeutic targets (Expert Opin Ther Targets). 2002;6:563-70. doi: 10.1517/14728222.6.5.563. PMID: 12387680

40. Edmondson RD, Vondriska TM, Biederman KJ, Zhang J, Jones RC, Zheng Y, Allen DL, Xiu JX, Cardwell EM, Pisano MR, Ping P. Protein kinase C e signaling complexes include metabolism- and transcription/translation-related proteins: complimentary separation techniques with LC/MS/MS. Mol Cell Proteomics. 2002;1:421-33. PMID: 12169683

39. Doble BW, Ping P, Fandrich RR, Cattini PA, Kardami E. Protein kinase C-e mediates phorbol ester-induced phosphorylation of connexin-43. Cell Adhes Commun. 2001;8:253-6. PMID: 12064598

38. Cross HR, Murphy E, Bolli R, Ping P, Steenbergen C. Expression of activated PKC epsilon (PKCe) protects the ischemic heart, without attenuating ischemic H(+) production. J Mol Cell Cardiol. 2002;34:361-7. doi: 10.1006/jmcc.2001.1518. PMID: 11945027

37. Baines CP, Zhang J, Wang GW, Zheng YT, Xiu JX, Cardwell EM, Bolli R, Ping P. Mitochondrial PKCe and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCe-MAPK interactions and differential MAPK activation in PKCe-induced cardioprotection. Circ Res. 2002;90:390-7. PMID: 11884367 ???????

35. Balafanova Z, Bolli R, Zhang J, Zheng Y, Pass JM, Bhatnagar A, Tang XL, Wang O, Cardwell E, Ping P. Nitric oxide (NO) induces nitration of protein kinase C epsilon (PKCe), facilitating PKCe enhanced PKCe-RACK2 interactions: a novel mechanism of no-triggered activation of PKCe. J Biol Chem. 2002;277:15021-15027. doi: 10.1074/jbc.M112451200. PMID: 11839754

34. Song C, Vondriska TM, Wang GW, Klein JB, Cao X, Zhang J, Kang YJ, D'Souza S, Ping P. Molecular conformation dictates signaling module formation: example of PKCe and Src tyrosine kinase. Am J Physiol Heart Circ Physiol. 2002;282:H1166-71. doi: 10.1152/ajpheart.00830.2001. PMID: 11834516

33. Pass JM, Gao J, Jones WK, Wead WB, Wu X, Zhang J, Baines CP, Bolli R, Zheng YT, Joshua IG, Ping P. Enhanced PKC beta II translocation and PKC beta II-RACK1 interactions in PKC epsilon-induced heart failure: a role for RACK1. Am J Physiol Heart Circ Physiol. 2001;281:H2500-10. PMID: 11709417

32. Vondriska TM, Zhang J, Song C, Tang XL, Cao X, Baines CP, Pass JM, Wang S, Bolli R, Ping P. Protein kinase C epsilon-Src modules direct signal transduction in nitric oxide-induced cardioprotection: complex formation as a means for cardioprotective signaling. Circ Res. 2001;88:1306-13. PMID: 11420308

31. Baines CP, Pass JM, Ping P. Protein kinases and kinase-modulated effectors in the late phase of ischemic preconditioning. Basic Res Cardiol. 2001;96:207-18. PMID: 11403414

30. Vondriska TM, Klein JB, Ping P. Use of functional proteomics to investigate PKC epsilon-mediated cardioprotection: the signaling module hypothesis. Am J Physiol Heart Circ Physiol. 2001;280:H1434-41. PMID: 11247751

29. Pass JM, Zheng Y, Wead WB, Zhang J, Li RC, Bolli R, Ping P. PKCepsilon activation induces dichotomous cardiac phenotypes and modulates PKCepsilon-RACK interactions and RACK expression. Am J Physiol Heart Circ Physiol. 2001;280:H946-55. PMID: 11179034

28. Ping P, Zhang J, Pierce WM Jr, Bolli R. Functional proteomic analysis of protein kinase C epsilon signaling complexes in the normal heart and during cardioprotection. Circ Res. 2001;88:59-62. PMID: 11139474

27. Rane MJ, Coxon PY, Powell DW, Webster R, Klein JB, Pierce W, Ping P, McLeish KR. p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils. J Biol Chem. 2001;276:3517-23. doi: 10.1074/jbc.M005953200. PMID: 11042204

26. Li RC, Ping P, Zhang J, Wead WB, Cao X, Gao J, Zheng Y, Huang S, Han J, Bolli R. PKCepsilon modulates NF-kappaB and AP-1 via mitogen-activated protein kinases in adult rabbit cardiomyocytes. Am J Physiol Heart Circ Physiol. 2000;279:H1679-89. PMID: 11009455

25. Takeishi Y, Ping P, Bolli R, Kirkpatrick DL, Hoit BD, Walsh RA. Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy. Circ Res. 2000;86:1218-23. PMID: 10864911

24. Ping P, Murphy E. Role of p38 mitogen-activated protein kinases in preconditioning: a detrimental factor or a protective kinase? Circ Res. 2000;86:921-2. PMID: 10807861

23. Doble BW, Ping P, Kardami E The epsilon subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation. Circ Res. 2000;86:293-301. PMID: 10679481

22. Dawn B, Xuan YT, Qiu Y, Takano H, Tang XL, Ping P, Banerjee S, Hill M, Bolli R. Bifunctional role of protein tyrosine kinases in late preconditioning against myocardial stunning in conscious rabbits. Circ Res. 1999;85:1154-63. PMID: 10590242

21. Ping P, Zhang J, Huang S, Cao X, Tang XL, Li RC, Zheng YT, Qiu Y, Clerk A, Sugden P, Han J, Bolli R. PKC-dependent activation of p46/p54 JNKs during ischemic preconditioning in conscious rabbits. Am J Physiol. 1999;277:H1771-85. PMID: 10564130

20. Guo Y, Jones WK, Xuan YT, Tang XL, Bao W, Wu WJ, Han H, Laubach VE, Ping P, Yang Z, Qiu Y, Bolli R. The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene. Proc Natl Acad Sci U S A. 1999;96:11507-12.  PMCID: PMC18064. PMID: 10500207

19. Ping P, Zhang J, Zheng YT, Li RC, Dawn B, Tang XL, Takano H, Balafanova Z, Bolli R.Demonstration of selective protein kinase C-dependent activation of Src and Lck tyrosine kinases during ischemic preconditioning in conscious rabbits. Circ Res. 1999;85:542-50. PMID: 10488057

18. Ping P, Zhang J, Cao X, Li RC, Kong D, Tang XL, Qiu Y, Manchikalapudi S, Auchampach JA, Black RG, Bolli R. PKC-dependent activation of p44/p42 MAPKs during myocardial ischemia-reperfusion in conscious rabbits. Am J Physiol. 1999;276:H1468-81. PMID: 10330229

17. Ping P, Takano H, Zhang J, Tang XL, Qiu Y, Li RC, Banerjee S, Dawn B, Balafonova Z, Bolli R. Isoform-selective activation of protein kinase C by nitric oxide in the heart of conscious rabbits: a signaling mechanism for both nitric oxide-induced and ischemia-induced preconditioning. Circ Res. 1999;84:587-604. PMID: 10082480

16. Bolli R, Dawn B, Tang XL, Qiu Y, Ping P, Xuan YT, Jones WK, Takano H, Guo Y, Zhang J. The nitric oxide hypothesis of late preconditioning. Basic Res Cardiol. 1998;93:325-38.  PMCID: PMC3701309. PMID: 9833145

15. Qiu Y, Ping P, Tang XL, Manchikalapudi S, Rizvi A, Zhang J, Takano H, Wu WJ, Teschner S, Bolli R. Direct evidence that protein kinase C plays an essential role in the development of late preconditioning against myocardial stunning in conscious rabbits and that epsilon is the isoform involved. J Clin Invest. 1998;101:2182-98. PMCID: PMC508806. PMID: 9593774

14. Gao M, Ping P, Post S, Insel PA, Tang R, Hammond HK. Increased expression of adenylylcyclase type VI proportionately increases beta-adrenergic receptor-stimulated production of cAMP in neonatal rat cardiac myocytes. Proc Natl Acad Sci U S A. 1998;95:1038-43.  PMCID: PMC18663. PMID: 9448281

13. Pal M, Toth A, Ping P, Johnson PC. Capillary blood flow and tissue metabolism in skeletal muscle during sympathetic trunk stimulation. Am J Physiol. 1998;274:H430-40. PMID: 9486245

12. Hammond HK, Ping P, Insel PA. Cardiac G-protein receptor kinase activity: effect of a beta-adrenergic receptor antagonist. Adv Pharmacol. 1998;42:507-10. PMID: 9327951

11. Ping P, Zhang J, Qiu Y, Tang XL, Manchikalapudi S, Cao X, Bolli R. Ischemic preconditioning induces selective translocation of protein kinase C isoforms epsilon and eta in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity. Circ Res. 1997;81:404-14. PMID: 9285643

10. Ping P, Anzai T, Gao M, Hammond HK. Adenylyl cyclase and G protein receptor kinase expression during development of heart failure. Am J Physiol. 1997;273:H707-17. PMID: 9277487

9. Ping P, Yang Q, Hammond HK. Altered beta-adrenergic receptor signaling in heart failure, in vivo gene transfer via adeno and adeno-associated virus. Microcirculation. 1996;3:225-8. PMID: 8839444

8. Giordano FJ, Ping P, McKirnan MD, Nozaki S, DeMaria AN, Dillmann WH, Mathieu-Costello O, Hammond HK. Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart. Nat Med. 1996;2:534-9. PMID: 8616711

7. Ping P, Gelzer-Bell R, Roth DA, Kiel D, Insel PA, Hammond HK. Reduced beta-adrenergic receptor activation decreases G-protein expression and beta-adrenergic receptor kinase activity in porcine heart. J Clin Invest. 1995;95:1271-80.  PMCID: PMC441466. PMID: 7883975

6. Ping P, Hammond HK. Diverse G protein and beta-adrenergic receptor mRNA expression in normal and failing porcine hearts. Am J Physiol. 1994;267:H2079-85. PMID: 7977840

5. Ping P, Johnson PC. Arteriolar network response to pressure reduction during sympathetic nerve stimulation in cat skeletal muscle. Am J Physiol. 1994;266:H1251-9. PMID: 8160830

4. Hammond HK, Roth DA, McKirnan MD, Ping P. Regional myocardial downregulation of the inhibitory guanosine triphosphate-binding protein (Gi alpha 2) and beta-adrenergic receptors in a porcine model of chronic episodic myocardial ischemia. J Clin Invest. 1993 Dec;92:2644-52. PMCID: PMC288461. PMID: 8254020

3. Ping P, Faber JE. Characterization of alpha-adrenoceptor gene expression in arterial and venous smooth muscle. Am J Physiol. 1993;265:H1501-9. PMID: 8238561

2. Ping P, Johnson PC. Role of myogenic response in enhancing autoregulation of flow during sympathetic nerve stimulation. Am J Physiol. 1992;263:H1177-84. PMID: 1415767

1. Ping P, Johnson PC. Mechanism of enhanced myogenic response in arterioles during sympathetic nerve stimulation. Am J Physiol. 1992;Oct;263(4 Pt 2):H1185-9. PMID: 1384361